Tyr52
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Home > Phosphorylation Site Page: > Tyr52  -  PKCD (human)

Site Information
VQKKPtMyPEWKSTF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447574

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
brain cancer ( 2 ) , glioblastoma ( 2 ) , glioma ( 2 )
Relevant cell line - cell type - tissue:
C6 (glial) ( 2 ) , platelet-blood ( 1 )

Upstream Regulation
Treatments:
collagen ( 1 ) , PAR1-activating_peptide ( 1 ) , PAR4-activating_peptide ( 1 ) , thrombin ( 1 ) , vanadate ( 1 ) , virus infection ( 2 )

Downstream Regulation
Effects of modification on PKCD:
activity, inhibited ( 2 )
Effects of modification on biological processes:
apoptosis, altered ( 2 )

References 

1

Hall KJ, Jones ML, Poole AW (2007) Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr311 and Tyr565 and phospholipase C signalling. Biochem J 406, 501-9
17570831   Curated Info

2

Zrachia A, et al. (2002) Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis. J Biol Chem 277, 23693-701
11927579   Curated Info