Ser165
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Home > Phosphorylation Site Page: > Ser165  -  JPH2 (mouse)

Site Information
PLRtsLSsLRSEHSN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4779179

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 4 ) , mass spectrometry ( 1 , 2 , 3 , 5 ) , mutation of modification site ( 4 )
Relevant cell line - cell type - tissue:
heart ( 2 , 3 ) , HL-1 (myocyte) [Akt1 (mouse), knockdown, stable lentiviral expression of Akt1 shRNA] ( 1 ) , HL-1 (myocyte) [Akt2 (mouse), knockdown, stable lentiviral expression of Akt2 shRNA] ( 1 ) , HL-1 (myocyte) ( 1 ) , kidney ( 3 ) , lung ( 3 ) , myoblast ( 4 ) , thymus ( 5 )

Upstream Regulation
Putative in vivo kinases:
PKCA (mouse) ( 4 )

Downstream Regulation
Effects of modification on JPH2:
molecular association, regulation ( 4 )
Induce interaction with:
TRPC3 (mouse) ( 4 )

References 

1

Reinartz M, Raupach A, Kaisers W, Gödecke A (2014) AKT1 and AKT2 induce distinct phosphorylation patterns in HL-1 cardiac myocytes. J Proteome Res 13, 4232-45
25162660   Curated Info

2

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

3

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

4

Woo JS, et al. (2010) S165F mutation of junctophilin 2 affects Ca2+ signalling in skeletal muscle. Biochem J 427, 125-34
20095964   Curated Info

5

Guo A (2009) CST Curation Set: 8170; Year: 2009; Biosample/Treatment: tissue, thymus/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y/M)Xp[ST](L/I/M)
Curated Info

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