Ser1179
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Home > Phosphorylation Site Page: > Ser1179  -  eNOS (human)

Site Information
RIRtQsFsLQERQLR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 467802

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 4 , 5 ) , mutation of modification site ( 1 , 7 ) , phospho-antibody ( 1 , 2 , 7 ) , western blotting ( 1 , 2 , 7 )
Disease tissue studied:
lung cancer ( 5 ) , non-small cell lung adenocarcinoma ( 5 ) , pancreatic ductal adenocarcinoma ( 4 )
Relevant cell line - cell type - tissue:
'pancreatic, ductal'-pancreas ( 4 ) , BAEC (endothelial) ( 1 ) , carotid artery ( 1 ) , EC (endothelial) ( 2 ) , HAEC (endothelial) ( 1 ) , HUVEC (endothelial) ( 7 ) , lung ( 5 )

Upstream Regulation
Regulatory protein:
Akt1 (human) ( 1 ) , Akt2 (human) ( 1 ) , Akt3 (human) ( 1 ) , CDK9 (human) ( 1 ) , CLK1 (human) ( 1 ) , DAPK3 (human) ( 1 ) , GSK3B (human) ( 1 ) , HIPK1 (human) ( 1 ) , LATS1 (human) ( 1 ) , MEK1 (human) ( 1 ) , MEKK3 (human) ( 1 ) , MPO (human) ( 2 ) , NLK (human) ( 1 ) , PAK2 (human) ( 1 ) , PDK1 (human) ( 1 ) , PIEZO1 (human) ( 1 ) , Pim3 (human) ( 1 ) , PKD2 (human) ( 1 ) , PKN1 (human) ( 1 ) , PKN2 (human) ( 1 ) , PKN3 (human) ( 1 ) , ROCK1 (human) ( 1 ) , SLK (human) ( 1 ) , SNRK (human) ( 1 ) , TAK1 (human) ( 1 ) , TRIO (human) ( 1 )
Putative in vivo kinases:
PKN2 (human) ( 1 )
Kinases, in vitro:
PKN2 (human) ( 1 )
Treatments:
BAPTA-AM ( 2 ) , Ca(2+) ( 2 ) , H2O2 ( 2 ) , Ki8751 ( 1 ) , laminar flow ( 1 ) , LY294002 ( 1 ) , PS48 ( 1 ) , simvastatin ( 7 ) , siRNA ( 1 ) , U73122 ( 2 ) , VEGF ( 7 ) , wortmannin ( 1 , 7 )

Downstream Regulation
Effects of modification on eNOS:
enzymatic activity, induced ( 1 , 2 , 7 )
Effects of modification on biological processes:
apoptosis, inhibited ( 7 )

References 

1

Jin YJ, et al. (2021) Protein kinase N2 mediates flow-induced eNOS activation and vascular tone regulation. J Clin Invest
34499618   Curated Info

2

Thai T, et al. (2021) Endothelial-Transcytosed Myeloperoxidase Activates Endothelial Nitric Oxide Synthase via a Phospholipase C-Dependent Calcium Signaling Pathway. Free Radic Biol Med
33539947   Curated Info

3

Jang S, Lee S, Park H (2020) ¿¿-Cyclodextrin Inhibits Monocytic Adhesion to Endothelial Cells through Nitric Oxide-Mediated Depletion of Cell Adhesion Molecules. Molecules
32781622   Curated Info

4

Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948
24670416   Curated Info

5

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

6

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

7

Kureishi Y, et al. (2000) The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 6, 1004-10
10973320   Curated Info

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