Ser334
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Home > Phosphorylation Site Page: > Ser334  -  RIPK1 (mouse)

Site Information
VPLPPsRsNsEQPGS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4728178

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
fibrosarcoma of soft tissue ( 1 )
Relevant cell line - cell type - tissue:
BV2 (microglia) ( 1 ) , L929 (fibroblast) ( 1 ) , MEF (fibroblast) ( 1 ) , pancreas ( 2 ) , spleen ( 2 )

Upstream Regulation
Putative in vivo kinases:
TAK1 (mouse) ( 1 )
Treatments:
TNF ( 1 )

Downstream Regulation
Effects of modification on RIPK1:
enzymatic activity, induced ( 1 ) , molecular association, regulation ( 1 )
Induce interaction with:
RIPK3 (mouse) ( 1 )

References 

1

Geng J, et al. (2017) Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nat Commun 8, 359
28842570   Curated Info

2

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info