Ser878
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Home > Phosphorylation Site Page: > Ser878  -  KIF20A (human)

Site Information
RILRsRRsPLLKsGP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4712595

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 3 , 5 , 6 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HeLa (cervical) ( 1 , 2 , 5 , 6 ) , Jurkat (T lymphocyte) ( 3 ) , SF9 ( 2 )

Upstream Regulation
Putative in vivo kinases:
AurB (human) ( 1 ) , CDK1 (human) ( 2 )
Kinases, in vitro:
AurB (human) ( 1 )
Putative upstream phosphatases:
PPP2CA (human) ( 1 )
Treatments:
nocodazole ( 2 ) , purvalanol ( 2 )

Downstream Regulation
Effects of modification on KIF20A:
intracellular localization ( 2 ) , molecular association, regulation ( 2 ) , protein conformation ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 1 , 2 ) , cytoskeletal reorganization ( 1 )
Inhibit interaction with:
AurB (human) ( 2 ) , INCENP (human) ( 2 )

References 

1

Fung SY, et al. (2017) Opposing Activities of Aurora B Kinase and B56-PP2A Phosphatase on MKlp2 Determine Abscission Timing. Curr Biol 27, 78-86
27939310   Curated Info

2

Kitagawa M, et al. (2014) Cdk1 coordinates timely activation of MKlp2 kinesin with relocation of the chromosome passenger complex for cytokinesis. Cell Rep 7, 166-79
24656812   Curated Info

3

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

4

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

5

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

6

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

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