Ser266
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Home > Phosphorylation Site Page: > Ser266  -  MEKK1 (human)

Site Information
GRTVKsEsPGVRRKR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4708628

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 5 )
Disease tissue studied:
breast cancer ( 3 ) , breast cancer, triple negative ( 3 ) , melanoma skin cancer ( 1 )
Relevant cell line - cell type - tissue:
breast ( 3 ) , HeLa (cervical) ( 2 ) , HeLa_Meta (cervical) ( 5 ) , HeLa_Pro (cervical) ( 5 ) , HeLa_Telo (cervical) ( 5 ) , WM239A (melanocyte) ( 1 )

Upstream Regulation
Treatments:
MG132_withdrawal ( 5 )

References 

1

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

5

Dulla K, et al. (2010) Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Mol Cell Proteomics 9, 1167-81
20097925   Curated Info