Ser195
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Home > Phosphorylation Site Page: > Ser195  -  LSP1 (mouse)

Site Information
KLADRTEsLNRsIKK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4704192

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 )
Disease tissue studied:
anthrax infection ( 6 ) , leukemia ( 4 ) , acute myelogenous leukemia ( 4 ) , melanoma skin cancer ( 8 )
Relevant cell line - cell type - tissue:
blood ( 4 ) , macrophage-bone marrow ( 7 ) , macrophage-bone marrow [DUSP1 (mouse), homozygous knockout] ( 7 ) , macrophage-peritoneum [MPRIP (mouse), homozygous knockout] ( 3 ) , RAW 264.7 (macrophage) ( 1 ) , skin [mGluR1 (mouse), transgenic, TG mutant mice] ( 8 ) , spleen ( 6 ) , stromal ( 2 ) , T lymphocyte-spleen ( 5 )

Upstream Regulation
Kinases, in vitro:
MAPKAPK2 (human) ( 9 )
Treatments:
LPS ( 7 )

References 

1

Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44
25367039   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

4

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

5

Navarro MN, et al. (2011) Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes. Nat Immunol 12, 352-61
21399638   Curated Info

6

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

7

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

8

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info

9

Huang CK, Zhan L, Ai Y, Jongstra J (1997) LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils. J Biol Chem 272, 17-9
8995217   Curated Info