Thr315

Site Information
tGsEAsstRRGGsLG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 4700736

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 3 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 3 ) , western blotting ( 1 )
Disease tissue studied:	leukemia ( 1 ) , lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:	BaF3 ('B lymphocyte, precursor') ( 1 ) , CHO (fibroblast) ( 3 ) , CHO-K1 (fibroblast) ( 1 ) , HeLa (cervical) ( 1 ) , HL60 (myeloid) ( 1 ) , lung ( 2 ) , RBL-2H3 (basophil) ( 1 )

Downstream Regulation
Effects of modification on LTB4R:	phosphorylation ( 1 ) , receptor internalization, induced ( 3 )
Effects of modification on biological processes:	signaling pathway regulation ( 1 )

References
1	Nakanishi Y, et al. (2018) Stepwise phosphorylation of leukotriene B receptor 1 defines cellular responses to leukotriene B. Sci Signal 11 30131369 Curated Info
2	Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96 23911959 Curated Info
3	Aratake Y, et al. (2012) Helix 8 of leukotriene B4 receptor 1 inhibits ligand-induced internalization. FASEB J 26, 4068-78 22707565 Curated Info