Tyr1363

Site Information
NVKCVAPyPSLLPSQ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 448474

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 )
Relevant cell line - cell type - tissue:	MDCK (epithelial) ( 1 , 2 )

Downstream Regulation
Effects of modification on Met:	molecular association, regulation ( 1 )
Effects of modification on biological processes:	cell motility, altered ( 2 ) , cytoskeletal reorganization ( 1 , 2 )
Induce interaction with:	GAB1 (mouse) ( 1 ) , GRB2 (mouse) ( 1 ) , PIK3C2A (mouse) ( 1 ) , SHC1 (mouse) ( 1 )

References
1	Tulasne D, et al. (1999) The multisubstrate docking site of the MET receptor is dispensable for MET-mediated RAS signaling and cell scattering. Mol Biol Cell 10, 551-65 10069803 Curated Info
2	Weidner KM, Sachs M, Riethmacher D, Birchmeier W (1995) Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells. Proc Natl Acad Sci U S A 92, 2597-601 7708691 Curated Info