Lys412
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Home > Ubiquitylation Site Page: > Lys412  -  IRF5 (human)

Site Information
DRKPREkkLITVQVV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4666600

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
dendritic cell ( 1 ) , HEK293T (epithelial) ( 2 ) , MEF (fibroblast) ( 2 )

Downstream Regulation
Effects of modification on IRF5:
intracellular localization ( 2 ) , molecular association, regulation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
transcription, induced ( 2 ) , transcription, inhibited ( 1 )
Induce interaction with:
LYN (human) ( 1 )

References 

1

Ban T, et al. (2016) Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity. Immunity 45, 319-32
27521268   Curated Info

2

Balkhi MY, Fitzgerald KA, Pitha PM (2008) Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination. Mol Cell Biol 28, 7296-308
18824541   Curated Info