Lys1901

Site Information
APSRKkAkEPTTQIT SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 4664711

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 )
Disease tissue studied:	neuroblastoma ( 1 ) , pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:	alphaT3-1 (pituitary cell) ( 1 , 2 ) , AR42J (pancreatic) ( 1 ) , Rat1 (fibroblast) ( 1 , 2 ) , SH-SY5Y (neural crest) ( 1 )

Upstream Regulation
Treatments:	endothelin ( 2 ) , GnRH ( 2 )

References
1	Sliter DA, Aguiar M, Gygi SP, Wojcikiewicz RJ (2011) Activated inositol 1,4,5-trisphosphate receptors are modified by homogeneous Lys-48- and Lys-63-linked ubiquitin chains, but only Lys-48-linked chains are required for degradation. J Biol Chem 286, 1074-82 21071436 Curated Info
2	Sliter DA, et al. (2008) Mass spectrometric analysis of type 1 inositol 1,4,5-trisphosphate receptor ubiquitination. J Biol Chem 283, 35319-28 18955483 Curated Info