Ser68
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser68  -  AHCYL1 (human)

Site Information
RSLSRSIsQSstdsY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 467244

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 4 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 3 ) , E.coli (bacterial) ( 2 ) , Jurkat (T lymphocyte) ( 4 ) , MEF (fibroblast) ( 2 ) , OKP (epithelial) ( 1 ) , SF9 ( 2 , 3 )

Downstream Regulation
Effects of modification on AHCYL1:
molecular association, regulation ( 1 )
Induce interaction with:
NHE3 (human) ( 1 ) , NHERF (human) ( 1 )

References 

1

He P, et al. (2016) The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II. Am J Physiol Renal Physiol 311, F343-51
27279487   Curated Info

2

Kawaai K, et al. (2015) IRBIT regulates CaMKII╬▒ activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation. Proc Natl Acad Sci U S A 112, 5515-20
25922519   Curated Info

3

Ando H, Mizutani A, Mikoshiba K (2009) An IRBIT homologue lacks binding activity to inositol 1,4,5-trisphosphate receptor due to the unique N-terminal appendage. J Neurochem 109, 539-50
19220705   Curated Info

4

Possemato A (2008) CST Curation Set: 3661; Year: 2008; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS:pSXXXpS
Curated Info