Thr336
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Home > Phosphorylation Site Page: > Thr336  -  AT1 (human)

Site Information
NLStKMstLsYRPsD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 467237

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on AT1:
activity, induced ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 , 2 ) , receptor internalization, altered ( 2 )
Induce interaction with:
ARRB1 (human) ( 1 , 2 ) , ARRB2 (human) ( 1 )

References 

1

Kule CE, et al. (2004) Agonist-dependent internalization of the angiotensin II type one receptor (AT1): role of C-terminus phosphorylation in recruitment of beta-arrestins. Regul Pept 120, 141-8
15177932   Curated Info

2

Qian H, Pipolo L, Thomas WG (2001) Association of beta-Arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization. Mol Endocrinol 15, 1706-19
11579203   Curated Info