Tyr1212
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Home > Phosphorylation Site Page: > Tyr1212  -  VEGFR2 (mouse)

Site Information
VCDPKFHyDNTAGIS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447902

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 3 , 4 ) , peptide sequencing ( 1 ) , phospho-antibody ( 2 , 3 , 4 ) , western blotting ( 1 , 3 , 4 )
Relevant cell line - cell type - tissue:
endothelial-aorta ( 1 ) , PAE (endothelial) ( 1 , 3 , 4 ) , vessel ( 2 )

Upstream Regulation
Kinases, in vitro:
VEGFR2 (mouse) ( 1 , 4 )
Treatments:
M-CSF ( 3 , 4 ) , VEGF ( 1 , 4 )

Downstream Regulation
Effects of modification on VEGFR2:
enzymatic activity, induced ( 3 , 4 ) , molecular association, regulation ( 4 ) , phosphorylation ( 4 )
Induce interaction with:
Src (human) ( 4 )

References 

1

Kawamura H, et al. (2008) Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity. Cancer Res 68, 4683-92
18559514   Curated Info

2

Matsumoto T, et al. (2005) VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. EMBO J 24, 2342-53
15962004   Curated Info

3

Meyer RD, et al. (2004) Substitution of C-terminus of VEGFR-2 with VEGFR-1 promotes VEGFR-1 activation and endothelial cell proliferation. Oncogene 23, 5523-31
15107818   Curated Info

4

Meyer RD, Dayanir V, Majnoun F, Rahimi N (2002) The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules. J Biol Chem 277, 27081-7
12023952   Curated Info

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