Tyr1173
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Home > Phosphorylation Site Page: > Tyr1173  -  VEGFR2 (mouse)

Site Information
AQQDGKDyIVLPMSE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447901

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 3 ) , peptide sequencing ( 6 ) , phospho-antibody ( 2 , 3 , 4 , 5 , 7 , 8 ) , western blotting ( 1 , 3 , 4 , 5 , 6 , 7 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , endothelial ( 7 ) , endothelial-aorta ( 2 , 6 ) , endothelial-pulmonary artery ( 5 ) , endothelial-vein ( 5 ) , ES (stem) ( 7 ) , microvessel endothelial [CBL (mouse), homozygous knockout] ( 4 ) , PAE (endothelial) ( 6 ) , vessel ( 8 )

Upstream Regulation
Regulatory protein:
CBL (mouse) ( 4 ) , GIPC1 (mouse) ( 5 ) , MYO6 (mouse) ( 5 ) , PTPRB (mouse) ( 5 ) , PTPRJ (mouse) ( 5 ) , PTPRM (mouse) ( 5 ) , VEGFR1 (mouse) ( 7 )
Putative upstream phosphatases:
PTP1B (mouse) ( 5 )
Treatments:
VEGF ( 4 , 5 , 6 )

Downstream Regulation
Effects of modification on VEGFR2:
activity, induced ( 3 ) , intracellular localization ( 5 ) , molecular association, regulation ( 2 ) , phosphorylation ( 3 ) , protein stabilization ( 3 ) , receptor internalization, induced ( 2 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 , 3 )

References 

1

Kanthou C, et al. (2014) Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics. PLoS One 9, e104015
25119572   Curated Info

2

Wu C, et al. (2011) Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis. J Biol Chem 286, 23511-20
21543326   Curated Info

3

Meyer RD, et al. (2011) PEST Motif Serine and Tyrosine Phosphorylation Controls Vascular Endothelial Growth Factor Receptor 2 Stability and Downregulation. Mol Cell Biol 31, 2010-25
21402774   Curated Info

4

Meyer RD, Husain D, Rahimi N (2011) c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCĪ³1. Oncogene 30, 2198-206
21242968   Curated Info

5

Lanahan AA, et al. (2010) VEGF receptor 2 endocytic trafficking regulates arterial morphogenesis. Dev Cell 18, 713-24
20434959   Curated Info

6

Kawamura H, et al. (2008) Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity. Cancer Res 68, 4683-92
18559514   Curated Info

7

Kappas NC, et al. (2008) The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching. J Cell Biol 181, 847-58
18504303   Curated Info

8

Matsumoto T, et al. (2005) VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. EMBO J 24, 2342-53
15962004   Curated Info