Tyr949
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Home > Phosphorylation Site Page: > Tyr949  -  VEGFR2 (mouse)

Site Information
RFRQGkDyVGELSVD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447903

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , phospho-antibody ( 2 )
Relevant cell line - cell type - tissue:
HUVEC (endothelial) ( 2 ) , PAE (endothelial) ( 2 ) , vessel ( 2 )

Upstream Regulation
Kinases, in vitro:
VEGFR2 (mouse) ( 1 )

Downstream Regulation
Effects of modification on VEGFR2:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell motility, altered ( 2 ) , cytoskeletal reorganization ( 2 )
Induce interaction with:
TSAd (mouse) ( 2 )

References 

1

Kawamura H, et al. (2008) Vascular endothelial growth factor (VEGF)-A165b is a weak in vitro agonist for VEGF receptor-2 due to lack of coreceptor binding and deficient regulation of kinase activity. Cancer Res 68, 4683-92
18559514   Curated Info

2

Matsumoto T, et al. (2005) VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. EMBO J 24, 2342-53
15962004   Curated Info