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Site Information |
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EtPPRPRtPGRPLsS SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 448287 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Putative in vivo kinases: | |
Kinases, in vitro: | |
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Downstream Regulation | |
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Effects of modification on MEK1: | |
Effects of modification on biological processes: | |
Induce interaction with: |
References | |
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Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201
21454597 Curated Info |
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Catalanotti F, et al. (2009) A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. Nat Struct Mol Biol 16, 294-303
19219045 Curated Info |
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Eblen ST, Slack JK, Weber MJ, Catling AD (2002) Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol Cell Biol 22, 6023-33
12167697 Curated Info |
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Brunet A, Pagès G, Pouysségur J (1994) Growth factor-stimulated MAP kinase induces rapid retrophosphorylation and inhibition of MAP kinase kinase (MEK1). FEBS Lett 346, 299-303
8013650 Curated Info |
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Gardner AM, Vaillancourt RR, Lange-Carter CA, Johnson GL (1994) MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase: analysis of phosphopeptides and regulation of activity. Mol Biol Cell 5, 193-201
8019005 Curated Info |