Tyr379
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Home > Phosphorylation Site Page: > Tyr379  -  HPK1 (mouse)

Site Information
LsDsDDDyDDVDIPA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448160

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 )
Relevant cell line - cell type - tissue:
B lymphocyte-spleen ( 2 ) , COS (fibroblast) ( 2 ) , Jurkat (T lymphocyte) ( 1 ) , WEHI-231 (B lymphocyte) ( 2 )

Upstream Regulation
Putative in vivo kinases:
Syk (mouse) ( 2 )
Treatments:
antibody ( 2 )

Downstream Regulation
Effects of modification on HPK1:
enzymatic activity, induced ( 1 , 2 ) , molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
transcription, altered ( 1 )
Induce interaction with:
BLNK (mouse) ( 1 , 2 ) , SLP76 (human) ( 1 )

References 

1

Sauer K, et al. (2001) Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes. J Biol Chem 276, 45207-16
11487585   Curated Info

2

Tsuji S, et al. (2001) B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1. J Exp Med 194, 529-39
11514608   Curated Info

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