Thr182
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Home > Phosphorylation Site Page: > Thr182  -  SIK (rat)

Site Information
KPGEPLStWCGsPPY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 456034

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 4 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 2 ) , C2C12 (myoblast) ( 3 ) , COS (fibroblast) ( 4 ) , liver ( 1 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (rat) ( 4 ) , LKB1 (human) ( 4 )
Kinases, in vitro:
GSK3B (human) ( 4 ) , GSK3B (rat) ( 3 )
Treatments:
acadesine ( 3 ) , BDNF ( 2 ) , bisindolylmaleimide ( 4 ) , H-89 ( 4 ) , Hypericin ( 4 ) , indirubin ( 3 , 4 ) , KN-93 ( 4 ) , LY294002 ( 3 ) , PD98059 ( 4 ) , Ro31-8220 ( 4 ) , SB203580 ( 4 ) , serum ( 3 ) , staurosporine ( 4 ) , STO-609 ( 4 ) , wortmannin ( 4 ) , Zhenqing Recipe ( 1 )

Downstream Regulation
Effects of modification on SIK:
enzymatic activity, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
diabetes mellitus ( 1 )

References 

1

Song D, Yin L, Wang C, Wen X (2020) Zhenqing recipe attenuates non-alcoholic fatty liver disease by regulating the SIK1/CRTC2 signaling in experimental diabetic rats. BMC Complement Med Ther
32020874   Curated Info

2

Finsterwald C, Carrard A, Martin JL (2013) Role of salt-inducible kinase 1 in the activation of MEF2-dependent transcription by BDNF. PLoS One 8, e54545
23349925   Curated Info

3

Takemori H, et al. (2009) Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts. Endocr J 56, 121-30
18946175   Curated Info

4

Hashimoto YK, Satoh T, Okamoto M, Takemori H (2008) Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity. J Cell Biochem 104, 1724-39
18348280   Curated Info

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