Ser2006

Site Information
DDGsLKsssPtSYWK SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 465849

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 )
Disease tissue studied:	breast cancer ( 1 ) , hepatocellular carcinoma, surrounding tissue ( 5 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 )
Relevant cell line - cell type - tissue:	A431 (epithelial) ( 6 ) , H2009 (pulmonary) ( 3 ) , H2077 (pulmonary) ( 3 ) , H2887 (pulmonary) ( 3 ) , H322M (pulmonary) ( 3 ) , HCC1359 (pulmonary) ( 3 ) , HCC366 (pulmonary) ( 3 ) , HCC4006 (pulmonary) ( 3 ) , HCC78 (pulmonary) ( 3 ) , HCC827 (pulmonary) ( 3 ) , hepatocyte-liver ( 5 ) , HMLER ('stem, breast cancer') [CXCR4 (human), knockdown] ( 1 ) , HMLER ('stem, breast cancer') ( 1 ) , HUES-9 ('stem, embryonic') ( 4 ) , LCLC-103H (pulmonary) ( 3 ) , liver ( 2 ) , LOU-NH91 (squamous) ( 3 ) , NCI-H1395 (pulmonary) ( 3 ) , NCI-H157 (pulmonary) ( 3 ) , NCI-H1666 (pulmonary) ( 3 ) , NCI-H2030 (pulmonary) ( 3 ) , NCI-H460 (pulmonary) ( 3 )

References
1	Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90 24782546 Curated Info
2	Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62 24275569 Curated Info
3	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
4	Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3 21406692 Curated Info
5	Han G, et al. (2010) Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis. Electrophoresis 31, 1080-9 20166139 Curated Info
6	MS This site is one of 509 sites observed by D. Stover et al using MS/FTMS of peptides from lysates of A431 cells grown either in vitro or as xenografts in BALB/c nu/nu mice. These sites were previously unpublished until now (July 27 2006). 66 sites were previously published in: Stover DR, et al. Differential phosphoprofiles of EGF and EGFR kinase inhibitor-treated human tumor cells and mouse xenografts Clin Proteomics 2004 Mar 01; 1(1): 69-80. Curated Info