Ser204
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Home > Phosphorylation Site Page: > Ser204  -  PTPRA (mouse)

Site Information
PLLARsPstNRKYPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447612

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 3 ) , mutation of modification site ( 2 , 4 , 5 ) , phospho-antibody ( 2 , 4 ) , western blotting ( 2 , 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) [PTPRA (mouse)] ( 5 ) , 293 (epithelial) ( 2 ) , fibroblast ( 4 ) , macrophage-peritoneum ( 1 ) , neuron-'brain, cerebral cortex' ( 4 ) , neuron-'brain, hippocampus' ( 4 ) , RAW 267.4 (macrophage) ( 3 )

Upstream Regulation
Regulatory protein:
NCAM1 (mouse) ( 4 )
Putative in vivo kinases:
CAMK2A (mouse) ( 4 ) , PKCA (human) ( 5 )
Kinases, in vitro:
CAMK2A (human) ( 4 ) , PKCA (rat) ( 5 )
Putative upstream phosphatases:
PPP2CA (mouse) ( 2 )
Phosphatases, in vitro:
PPP2CA (human) ( 2 )
Treatments:
anti-NCAM ( 4 ) , calyculin_A ( 2 ) , IFN-gamma ( 3 ) , KN-62 ( 4 ) , nocodazole ( 2 ) , okadaic_acid ( 2 ) , phorbol_ester ( 5 ) , siRNA ( 2 ) , tautomycin ( 2 ) , taxol ( 2 )

Downstream Regulation
Effects of modification on PTPRA:
enzymatic activity, induced ( 4 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 4 )
Inhibit interaction with:
Src (mouse) ( 2 )

References 

1

Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51
22942356   Curated Info

2

Vacaru AM, den Hertog J (2010) Serine Dephosphorylation of Receptor Protein Tyrosine Phosphatase {alpha} in Mitosis Induces Src Binding and Activation. Mol Cell Biol 30, 2850-61
20385765   Curated Info

3

Trost M, et al. (2009) The phagosomal proteome in interferon-gamma-activated macrophages. Immunity 30, 143-54
19144319   Curated Info

4

Bodrikov V, et al. (2008) NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth. J Cell Biol 182, 1185-200
18809727   Curated Info

5

Tracy S, van der Geer P, Hunter T (1995) The receptor-like protein-tyrosine phosphatase, RPTP alpha, is phosphorylated by protein kinase C on two serines close to the inner face of the plasma membrane. J Biol Chem 270, 10587-94
7537734   Curated Info