Ser847
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Home > Phosphorylation Site Page: > Ser847  -  CDH1 (human)

Site Information
sEAAsLSsLNsSEsD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 465568

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , HEK293T (epithelial) ( 1 )

Upstream Regulation
Regulatory protein:
PBK (human) ( 1 )
Kinases, in vitro:
CK2A1 (human) ( 3 )

Downstream Regulation
Effects of modification on CDH1:
protein stabilization ( 1 )
Effects of modification on biological processes:
carcinogenesis, altered ( 1 ) , cell motility, inhibited ( 1 )

References 

1

Koshino A, et al. (2021) PBK Enhances Cellular Proliferation With Histone H3 Phosphorylation and Suppresses Migration and Invasion With CDH1 Stabilization in Colorectal Cancer. Front Pharmacol 12, 772926
35115926   Curated Info

2

Inuzuka H, et al. (2012) Acetylation-dependent regulation of skp2 function. Cell 150, 179-93
22770219   Curated Info

3

Dupre-Crochet S, et al. (2007) Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts. Mol Cell Biol 27, 3804-16
17353278   Curated Info

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