Tyr1063
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Home > Phosphorylation Site Page: > Tyr1063  -  Ret (mouse)

Site Information
TWIENKLyGMSDPNW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447625

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 3 , 4 , 5 , 6 ) , phospho-antibody ( 1 , 5 , 6 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Ret (mouse) ( 6 )
Treatments:
EGF ( 6 ) , GDNF ( 5 ) , pressure ( 1 )

Downstream Regulation
Effects of modification on Ret:
enzymatic activity, induced ( 1 ) , molecular association, regulation ( 4 , 5 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 5 )
Induce interaction with:
DOK1 (mouse) ( 4 ) , DOK2 (mouse) ( 5 ) , DOK4 (mouse) ( 5 ) , DOK5 (mouse) ( 5 )

References 

1

Fernández-Sánchez ME, et al. (2015) Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure. Nature 523, 92-5
25970250   Curated Info

2

Ohgami N, et al. (2012) Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice. Neurobiol Aging 33, 626.e25-34
21612845   Curated Info

3

Iavarone C, et al. (2006) Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. J Biol Chem 281, 10567-76
16484222   Curated Info

4

Murakami H, et al. (2002) Role of Dok1 in cell signaling mediated by RET tyrosine kinase. J Biol Chem 277, 32781-90
12087092   Curated Info

5

Grimm J, et al. (2001) Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol 154, 345-54
11470823   Curated Info

6

Salvatore D, et al. (2000) Tyrosines 1015 and 1062 are in vivo autophosphorylation sites in ret and ret-derived oncoproteins. J Clin Endocrinol Metab 85, 3898-907
11061555   Curated Info