Ser579
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Home > Phosphorylation Site Page: > Ser579  -  AR (human)

Site Information
YGALTCGsCKVFFKR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4275600

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 2 ) , electrophoretic mobility shift ( 3 ) , immunoassay ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
endometrial cancer ( 3 ) , endometrial adenocarcinoma ( 3 ) , prostate cancer ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PAK6 (human) ( 2 ) , PKCA (human) ( 1 , 2 )
Kinases, in vitro:
PAK6 (human) ( 2 ) , PKCA (human) ( 3 )
Treatments:
androstanolone ( 2 ) , EGF ( 3 ) , Sc-3007 ( 2 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on AR:
activity, induced ( 1 ) , intracellular localization ( 1 , 2 , 3 ) , molecular association, regulation ( 2 , 3 ) , protein degradation ( 2 ) , ubiquitination ( 2 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 2 ) , transcription, induced ( 3 )
Induce interaction with:
MDM2 (human) ( 2 )
Inhibit interaction with:
Ku70 (human) ( 3 ) , Ku80 (human) ( 3 )

Disease / Diagnostics Relevance
Relevant diseases:
prostate cancer ( 1 )

References 

1

Patek S, et al. (2017) Androgen receptor phosphorylation status at serine 578 predicts poor outcome in prostate cancer patients. Oncotarget 8, 4875-4887
27902483   Curated Info

2

Liu T, et al. (2013) p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2). J Biol Chem 288, 3359-69
23132866   Curated Info

3

Ponguta LA, Gregory CW, French FS, Wilson EM (2008) Site-specific androgen receptor serine phosphorylation linked to epidermal growth factor-dependent growth of castration-recurrent prostate cancer. J Biol Chem 283, 20989-1001
18511414   Curated Info