Ser244
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Home > Phosphorylation Site Page: > Ser244  -  PIK3C3 (human)

Site Information
EkDGDESsPILTsFE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4270306

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 , 6 , 7 , 8 ) , mass spectrometry (in vitro) ( 5 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
'stem, embryonic' ( 6 ) , A498 (renal) ( 4 ) , breast ( 1 ) , HCT116 (intestinal) ( 7 ) , HEK293T (epithelial) ( 5 ) , HeLa (cervical) ( 2 ) , HeLa S3 (cervical) ( 8 ) , HeLa_Meta (cervical) ( 3 ) , HeLa_Pro (cervical) ( 3 ) , HeLa_Telo (cervical) ( 3 ) , K562 (erythroid) ( 2 ) , MDA-MB-435S (breast cell) ( 7 ) , MV4-11 (macrophage) ( 7 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

3

Dulla K, et al. (2010) Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Mol Cell Proteomics 9, 1167-81
20097925   Curated Info

4

Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62
20071362   Curated Info

5

Furuya T, et al. (2010) Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell 38, 500-11
20513426   Curated Info

6

Brill LM, et al. (2009) Phosphoproteomic analysis of human embryonic stem cells. Cell Stem Cell 5, 204-13
19664994   Curated Info

7

Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195   Curated Info

8

Daub H, et al. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 31, 438-48
18691976   Curated Info