Thr72
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Home > Phosphorylation Site Page: > Thr72  -  Ets-2 (mouse)

Site Information
SCELPLLtPCSKAVM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447688

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 3 , 4 ) , western blotting ( 4 )
Relevant cell line - cell type - tissue:
'macrophage, alveolar'-lung ( 1 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 4 ) , lung ( 1 ) , macrophage-bone marrow ( 1 , 2 , 3 , 4 ) , macrophage-peritoneum ( 1 ) , MMTV-PyMT (breast cell) ( 2 ) , RAW 264 (macrophage) ( 3 , 4 )

Upstream Regulation
Kinases, in vitro:
ERK1 (mouse) ( 4 ) , ERK2 (mouse) ( 4 ) , JNK2 (mouse) ( 3 )
Treatments:
LY294002 ( 3 ) , M-CSF ( 3 , 4 ) , PD98059 ( 4 )

Downstream Regulation
Effects of modification on Ets-2:
activity, induced ( 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , transcription, altered ( 3 ) , transcription, induced ( 1 )

References 

1

Wei G, et al. (2004) Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model. J Immunol 173, 1374-9
15240733   Curated Info

2

Man AK, et al. (2003) Ets2-dependent stromal regulation of mouse mammary tumors. Mol Cell Biol 23, 8614-25
14612405   Curated Info

3

Smith JL, et al. (2000) ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice. Mol Cell Biol 20, 8026-34
11027273   Curated Info

4

Fowles LF, et al. (1998) Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating factor 1/c-fms signaling. Mol Cell Biol 18, 5148-56
9710599   Curated Info