Lys382
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Di-methylation Site Page: > Lys382  -  p53 (human)

Site Information
QstsRHkkLMFktEG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4219800

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
bone cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
neocarzinostatin ( 2 )

Downstream Regulation
Effects of modification on p53:
molecular association, regulation ( 2 ) , protein stabilization ( 2 )
Induce interaction with:
53BP1 (human) ( 2 )

References 

1

Tong Q, et al. (2015) An Acetyl-Methyl Switch Drives a Conformational Change in p53. Structure 23, 322-31
25651062   Curated Info

2

Kachirskaia I, et al. (2008) Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling. J Biol Chem 283, 34660-6
18840612   Curated Info