Ser901
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Home > Phosphorylation Site Page: > Ser901  -  mGluR5 iso2 (rat)

Site Information
QHLWQRLsVHINKKE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4213805

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'neuron, hippocampal' ( 2 ) , HeLa (cervical) ( 1 , 2 )

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 2 ) , PKCA (rat) ( 1 )
Treatments:
bisindolylmaleimide ( 2 ) , DHPG ( 2 ) , phorbol_ester ( 2 )

Downstream Regulation
Effects of modification on mGluR5 iso2:
intracellular localization ( 2 ) , molecular association, regulation ( 1 , 2 ) , protein degradation ( 1 )
Inhibit interaction with:
Calmodulin (human) ( 2 ) , Calmodulin (rat) ( 1 )

References 

1

Ko SJ, et al. (2012) PKC phosphorylation regulates mGluR5 trafficking by enhancing binding of Siah-1A. J Neurosci 32, 16391-401
23152621   Curated Info

2

Lee JH, et al. (2008) Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5. Proc Natl Acad Sci U S A 105, 12575-80
18715999   Curated Info