Thr323
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Home > Phosphorylation Site Page: > Thr323  -  HSF1 (human)

Site Information
GRPssVDtLLsPTAL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4169776

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 , 4 , 5 , 6 , 7 ) , mutation of modification site ( 2 )
Disease tissue studied:
breast cancer ( 1 ) , cervical cancer ( 4 ) , cervical adenocarcinoma ( 4 )
Relevant cell line - cell type - tissue:
'stem, embryonic' ( 5 ) , 293T (epithelial) ( 3 ) , BT-474 (breast cell) ( 1 ) , HeLa (cervical) ( 2 , 7 ) , HeLa S3 (cervical) ( 4 ) , Jurkat (T lymphocyte) ( 6 ) , MEF (fibroblast) ( 2 )

Upstream Regulation
Treatments:
anti-CD3 ( 6 ) , nocodazole ( 4 )

Downstream Regulation
Effects of modification on biological processes:
transcription, inhibited ( 2 )

References 

1

Carrier M, et al. (2016) Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines. PLoS One 11, e0157290
27362937   Curated Info

2

BudzyƄski MA, Puustinen MC, Joutsen J, Sistonen L (2015) Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation. Mol Cell Biol 35, 2530-40
25963659   Curated Info

3

Franchin C, et al. (2015) Quantitative analysis of a phosphoproteome readily altered by the protein kinase CK2 inhibitor quinalizarin in HEK-293T cells. Biochim Biophys Acta 1854, 609-23
25278378   Curated Info

4

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

5

Brill LM, et al. (2009) Phosphoproteomic analysis of human embryonic stem cells. Cell Stem Cell 5, 204-13
19664994   Curated Info

6

Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46
19690332   Curated Info

7

Cantin GT, et al. (2008) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J Proteome Res 7, 1346-51
18220336   Curated Info