Ser1070
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Home > Phosphorylation Site Page: > Ser1070  -  EGFR (mouse)

Site Information
DAFLQRyssDPtGAV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448051

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
bladder cancer ( 2 ) , pancreatic cancer ( 1 )
Relevant cell line - cell type - tissue:
bladder ( 2 ) , CD18/HPAF (pancreatic) ( 1 ) , COLO-357 (pancreatic) ( 1 ) , MEF (fibroblast) [PTP1B (mouse), homozygous knockout] ( 3 ) , MEF (fibroblast) ( 3 )

Upstream Regulation
Regulatory protein:
MUC4 (human) ( 1 )
Treatments:
amphiregulin ( 1 ) , EGF ( 1 ) , HB-EGF ( 1 )

Downstream Regulation
Effects of modification on biological processes:
carcinogenesis, induced ( 1 )

References 

1

Bhatia R, et al. (2023) Muc4 loss mitigates epidermal growth factor receptor activity essential for PDAC tumorigenesis. Oncogene
36624189   Curated Info

2

Bhuvaneswari R, Gan YY, Soo KC, Olivo M (2009) Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response. Mol Cancer 8, 94
19878607   Curated Info

3

Mertins P, et al. (2008) Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics 7, 1763-77
18515860   Curated Info

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