Ser102
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus®
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser102  -  GLI1 (human)

Site Information
LQTVIRTsPSSLVAF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 41595602

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , 3T3 (fibroblast) ( 1 , 2 ) , HEK193T (epithelial) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:
AMPKA2 (human) ( 2 )
Kinases, in vitro:
AMPKA2 (human) ( 2 )
Treatments:
A79662 ( 2 ) , acadesine ( 2 )

Downstream Regulation
Effects of modification on GLI1:
activity, inhibited ( 2 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , protein degradation ( 1 , 2 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 2 ) , cell growth, inhibited ( 2 )
Induce interaction with:
BTRC (human) ( 1 )

References 

1

Zhang R, et al. (2017) Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation. Oncotarget 8, 49869-49881
28562331   Curated Info

2

Li YH, et al. (2015) AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma. Cell Rep 12, 599-609
26190112   Curated Info