Thr1074
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Home > Phosphorylation Site Page: > Thr1074  -  GLI1 (human)

Site Information
QRGSsGHtPPPsGPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 41595601

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 4 , 5 ) , mass spectrometry ( 4 , 5 ) , mutation of modification site ( 2 , 4 , 5 ) , phospho-antibody ( 2 , 3 , 4 , 5 ) , western blotting ( 2 , 3 , 4 , 5 )
Disease tissue studied:
brain cancer ( 2 ) , medulloblastoma ( 2 ) , lymphoma ( 4 ) , B cell lymphoma ( 4 ) , non-Hodgkin's lymphoma ( 4 ) , follicular lymphoma ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AMPKA2 (human) ( 5 ) , MEKK3 (human) ( 2 )
Kinases, in vitro:
AMPKA2 (human) ( 5 )
Treatments:
A79662 ( 5 ) , acadesine ( 5 )

Downstream Regulation
Effects of modification on GLI1:
activity, inhibited ( 5 ) , intracellular localization ( 2 , 3 ) , molecular association, regulation ( 2 , 3 ) , protein degradation ( 3 , 5 ) , ubiquitination ( 3 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 5 ) , cell growth, inhibited ( 5 ) , transcription, inhibited ( 2 )
Induce interaction with:
BTRC (human) ( 3 ) , SUFU (human) ( 2 )
Inhibit interaction with:
DNA ( 2 )

References 

1

Asha K, Balfe N, Sharma-Walia N (2020) Concurrent Control of KSHV Life Cycle through Chromatin Modulation and Host Hedgehog Signaling: A New Prospect to the Therapeutic Potential of Lipoxin A4. J Virol
32102879   Curated Info

2

Lu J, et al. (2018) MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function. Oncogene
29662197   Curated Info

3

Zhang R, et al. (2017) Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation. Oncotarget 8, 49869-49881
28562331   Curated Info

4

Agarwal NK, et al. (2016) Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma. Blood 127, 605-15
26603838   Curated Info

5

Li YH, et al. (2015) AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma. Cell Rep 12, 599-609
26190112   Curated Info