Ser50
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Home > Phosphorylation Site Page: > Ser50  -  SNAPIN (human)

Site Information
HVHAVREsQVELREQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448453

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:
'neuron, hippocampal'-brain ( 2 ) , INS-1 (pancreatic) ( 1 )

Upstream Regulation
Regulatory protein:
PKACA (human) ( 2 )
Putative in vivo kinases:
PKACA (human) ( 1 )
Treatments:
exenatide ( 1 ) , mPKI ( 1 )

Downstream Regulation
Effects of modification on SNAPIN:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
exocytosis, induced ( 2 ) , neural plasticity ( 2 )
Induce interaction with:
RAPGEF4 (human) ( 1 ) , SNAP-25 (human) ( 1 ) , TMEM27 (human) ( 1 ) , VAMP2 (human) ( 1 )

References 

1

Song WJ, et al. (2011) Snapin mediates incretin action and augments glucose-dependent insulin secretion. Cell Metab 13, 308-19
21356520   Curated Info

2

Thakur P, Stevens DR, Sheng ZH, Rettig J (2004) Effects of PKA-mediated phosphorylation of Snapin on synaptic transmission in cultured hippocampal neurons. J Neurosci 24, 6476-81
15269257   Curated Info