Ser9

Site Information
VADPPRDskGLAAAE SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 4149276

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 6 , 7 , 9 , 10 )
Disease tissue studied:	breast cancer ( 7 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 ) , lung cancer ( 7 ) , non-small cell lung cancer ( 7 ) , melanoma skin cancer ( 2 )
Relevant cell line - cell type - tissue:	breast ( 1 ) , BT-20 (breast cell) ( 7 ) , BT-549 (breast cell) ( 7 ) , H2009 (pulmonary) ( 7 ) , H2077 (pulmonary) ( 7 ) , H2887 (pulmonary) ( 7 ) , H322M (pulmonary) ( 7 ) , HCC2279 (pulmonary) ( 7 ) , HCC366 (pulmonary) ( 7 ) , HCC78 (pulmonary) ( 7 ) , HeLa (cervical) ( 3 ) , HOP62 (pulmonary) ( 7 ) , HUES-9 ('stem, embryonic') ( 9 ) , K562 (erythroid) ( 6 ) , LOU-NH91 (squamous) ( 7 ) , MDA-MB-231 (breast cell) ( 7 ) , MDA-MB-468 (breast cell) ( 7 ) , NCI-H1395 (pulmonary) ( 7 ) , NCI-H1568 (pulmonary) ( 7 ) , NCI-H157 (pulmonary) ( 7 ) , NCI-H1666 (pulmonary) ( 7 ) , NCI-H2030 (pulmonary) ( 7 ) , NCI-H2172 (pulmonary) ( 7 ) , NCI-H322 (pulmonary) ( 7 ) , NCI-H460 (pulmonary) ( 7 ) , NCI-H647 (pulmonary) ( 7 ) , TERT20 ('stem, mesenchymal') ( 10 ) , WM239A (melanocyte) ( 2 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
3	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
4	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
5	Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21 23312004 Curated Info
6	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
7	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
8	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
9	Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3 21406692 Curated Info
10	Thingholm TE, et al. (2008) TiO2-Based Phosphoproteomic Analysis of the Plasma Membrane and the Effects of Phosphatase Inhibitor Treatment. J Proteome Res 7, 3304-3313 18578522 Curated Info