Lys383
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Home > Ubiquitylation Site Page: > Lys383  -  p53 (mouse)

Site Information
RHkkTMVkkVGPDsD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 464662

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 2 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:
'stem, embryonic' ( 3 ) , fibroblast-embryo ( 2 , 3 ) , NCI-H1299 (pulmonary) ( 1 ) , thymocyte ( 3 )

Downstream Regulation
Effects of modification on biological processes:
transcription, altered ( 3 )

References 

1

Ohtsubo C, et al. (2009) Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2. Cancer Sci 100, 1291-9
19432880   Curated Info

2

Krummel KA, Lee CJ, Toledo F, Wahl GM (2005) The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci U S A 102, 10188-93
16006521   Curated Info

3

Feng L, et al. (2005) Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol 25, 5389-95
15964796   Curated Info