Lys382
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Home > Mono-methylation Site Page: > Lys382  -  p53 (human)

Site Information
QstsRHkkLMFktEG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4061501

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 )
Disease tissue studied:
testicular cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on p53:
activity, inhibited ( 1 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 ) , transcription, inhibited ( 1 )

References 

1

Zhu J, et al. (2016) Lysine methylation represses p53 activity in teratocarcinoma cancer cells. Proc Natl Acad Sci U S A 113, 9822-7
27535933   Curated Info

2

Shi X, et al. (2007) Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell 27, 636-46
17707234   Curated Info