Lys538
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Home > Acetylation Site Page: > Lys538  -  BMAL1 iso4 (mouse)

Site Information
DASSPGGkKILNGGT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1968606

In vivo Characterization
Methods used to characterize site in vivo:
modification-specific antibody ( 1 , 2 ) , mutation of modification site ( 3 ) , phospho-antibody ( 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
COS7 (fibroblast) ( 3 ) , liver ( 2 ) , MEF (fibroblast) ( 3 ) , muscle ( 2 ) , skin ( 1 )

Upstream Regulation
Treatments:
fasting ( 2 )

Downstream Regulation
Effects of modification on BMAL1 iso4:
activity, induced ( 1 ) , molecular association, regulation ( 3 )
Effects of modification on biological processes:
transcription, altered ( 1 )
Induce interaction with:
CK2B (mouse) ( 3 )

References 

1

Welz PS, et al. (2019) BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis. Cell 177, 1436-1447.e12
31150620   Curated Info

2

Kinouchi K, et al. (2018) Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle. Cell Rep
30566858   Curated Info

3

Tamaru T, et al. (2015) CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock. PLoS Biol 13, e1002293
26562092   Curated Info