Tyr414
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Home > Phosphorylation Site Page: > Tyr414  -  DDX41 (human)

Site Information
DVIQEVEyVkEEAKM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 40253300

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , macrophage-bone marrow ( 1 ) , PC9 (pulmonary) ( 2 ) , PC9-IR (pulmonary) ( 2 )

Upstream Regulation
Putative in vivo kinases:
Btk (human) ( 1 )
Kinases, in vitro:
Btk (human) ( 1 )

Downstream Regulation
Effects of modification on DDX41:
molecular association, regulation ( 1 )
Induce interaction with:
DNA ( 1 ) , STING (human) ( 1 )

References 

1

Lee KG, et al. (2015) Bruton's Tyrosine Kinase Phosphorylates DDX41 and Activates Its Binding of dsDNA and STING to Initiate Type 1 Interferon Response. Cell Rep 10, 1055-65
25704810   Curated Info

2

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info