Ser133
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Home > Phosphorylation Site Page: > Ser133  -  CREM (mouse)

Site Information
EILSRRPsYRKILNE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448412

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 , 3 , 4 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phosphoamino acid analysis ( 2 , 3 , 4 ) , phosphopeptide mapping ( 2 , 3 , 4 )
Disease tissue studied:
gestational cancer ( 2 ) , gestational trophoblastic choriocarcinoma ( 2 ) , lymphoma ( 1 ) , B cell lymphoma ( 1 ) , pituitary cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
p70S6K (mouse) ( 2 )
Kinases, in vitro:
CAMK2A (mouse) ( 4 ) , CDK1 (mouse) ( 3 , 4 ) , p70S6K (mouse) ( 2 ) , PKACA (mouse) ( 3 , 4 ) , PKCA (human) ( 2 ) , PKCA (mouse) ( 4 )
Treatments:
A23187 ( 4 ) , cAMP_analog ( 4 ) , colforsin ( 4 ) , phorbol_ester ( 4 ) , rapamycin ( 2 ) , serum ( 2 )

Downstream Regulation
Effects of modification on CREM:
activity, induced ( 2 ) , activity, inhibited ( 3 )
Effects of modification on biological processes:
transcription, altered ( 3 ) , transcription, induced ( 1 , 2 , 4 )

References 

1

Nguyên TL, et al. (2007) Transcriptional regulation of the bovine leukemia virus promoter by the cyclic AMP-response element modulator tau isoform. J Biol Chem 282, 20854-67
17526487   Curated Info

2

de Groot RP, Ballou LM, Sassone-Corsi P (1994) Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression. Cell 79, 81-91
7923380   Curated Info

3

de Groot RP, Derua R, Goris J, Sassone-Corsi P (1993) Phosphorylation and negative regulation of the transcriptional activator CREM by p34cdc2. Mol Endocrinol 7, 1495-50
8114763   Curated Info

4

de Groot RP, et al. (1993) Multiple and cooperative phosphorylation events regulate the CREM activator function. EMBO J 12, 3903-11
8404858   Curated Info