Thr280
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr280  -  MEKK1 (mouse)

Site Information
PFQSGRItPPRRAPs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3951974

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'renal, podocyte' ( 1 )

Upstream Regulation
Putative in vivo kinases:
CDK5 (mouse) ( 1 )
Treatments:
tunicamycin ( 1 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 1 )

References 

1

Zhang Y, et al. (2017) Cyclin-dependent kinase 5 contributes to endoplasmic reticulum stress induced podocyte apoptosis via promoting MEKK1 phosphorylation at Ser280 in diabetic nephropathy. Cell Signal 31, 31-40
28024901   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info