Arg249
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Home > Phosphorylation Site Page: > Arg249  -  p53 (human)

Site Information
CMGGMNRrPILTIIT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 394791401

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , western blotting ( 3 )
Disease tissue studied:
liver cancer ( 3 ) , hepatocellular carcinoma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CDK4 (human) ( 3 )
Kinases, in vitro:
CDK4 (human) ( 3 )

Downstream Regulation
Effects of modification on p53:
intracellular localization ( 3 ) , molecular association, regulation ( 3 )
Effects of modification on biological processes:
cell growth, induced ( 3 ) , transcription, induced ( 3 )
Induce interaction with:
Myc (human) ( 3 ) , PIN1 (human) ( 3 )

Disease / Diagnostics Relevance
Relevant diseases:
hepatocellular carcinoma ( 3 )

References 

1

Wang H, et al. (2020) Nicotine Promotes WRL68 Cells Proliferation Due to the Mutant p53 Gain-of-Function by Activating CDK6-p53-RS-PIN1-STAT1 Signaling Pathway. Chem Res Toxicol
32820905   Curated Info

2

Wang H, Liao P, Zeng SX, Lu H (2019) Co-targeting p53-R249S and CDK4 synergistically suppresses survival of hepatocellular carcinoma cells. Cancer Biol Ther, 1-9
31747859   Curated Info

3

Liao P, et al. (2017) Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding. Mol Cell 68, 1134-1146.e6
29225033   Curated Info