Ser756
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Home > Phosphorylation Site Page: > Ser756  -  ITGB2 (human)

Site Information
NDNPLFksAtttVMN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448534

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 , 6 ) , mass spectrometry ( 1 , 2 , 3 ) , peptide sequencing ( 4 ) , phospho-antibody ( 5 ) , phosphoamino acid analysis ( 4 ) , phosphopeptide mapping ( 4 , 6 ) , western blotting ( 5 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , COS (fibroblast) ( 4 ) , Jurkat (T lymphocyte) ( 3 ) , lung ( 2 ) , neutrophil-blood ( 5 ) , T lymphocyte-blood ( 6 ) , TK-1 (T lymphocyte) ( 4 )

Upstream Regulation
Treatments:
A23187 ( 5 ) , anti-CD3 ( 5 ) , calpeptin ( 5 ) , okadaic_acid ( 5 , 6 ) , PD98059 ( 5 ) , phorbol_ester ( 4 , 5 , 6 ) , Ro31-8220 ( 5 ) , trifluoperazine ( 5 ) , W-7 ( 5 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

3

Possemato A (2008) CST Curation Set: 4738; Year: 2008; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (K/R)XX[ST]
Curated Info

4

Hilden TJ, Valmu L, Kärkkäinen S, Gahmberg CG (2003) Threonine phosphorylation sites in the beta 2 and beta 7 leukocyte integrin polypeptides. J Immunol 170, 4170-7
12682249   Curated Info

5

Fagerholm S, Morrice N, Gahmberg CG, Cohen P (2002) Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes. J Biol Chem 277, 1728-38
11700305   Curated Info

6

Valmu L, Hilden TJ, van Willigen G, Gahmberg CG (1999) Characterization of beta2 (CD18) integrin phosphorylation in phorbol ester-activated T lymphocytes. Biochem J 339 ( Pt 1), 119-25
10085235   Curated Info