Ser68
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Home > Phosphorylation Site Page: > Ser68  -  CENPA (human)

Site Information
LIRKLPFsRLAREIC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 38520200

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 , 4 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 2 , 4 ) , western blotting ( 1 , 2 , 4 )
Disease tissue studied:
bone cancer ( 3 ) , colorectal cancer ( 2 , 3 ) , colorectal carcinoma ( 2 , 3 )
Relevant cell line - cell type - tissue:
DLD1 (intestinal) ( 2 , 3 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , MCF10A1 (epithelial) ( 2 ) , RPE-1 (retinal) ( 3 ) , U2OS (bone cell) ( 3 )

Upstream Regulation
Putative in vivo kinases:
CDK1 (human) ( 2 , 4 )
Kinases, in vitro:
CDK1 (human) ( 4 )
Putative upstream phosphatases:
PPP1CA (human) ( 4 )

Downstream Regulation
Effects of modification on CENPA:
intracellular localization ( 1 ) , protein degradation ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )

References 

1

Wang K, et al. (2021) Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle. Cell Rep 37, 109987
34758320   Curated Info

2

Takada M, et al. (2017) FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A. Cancer Res 77, 4881-4893
28760857   Curated Info

3

Fachinetti D, et al. (2017) CENP-A Modifications on Ser68 and Lys124 Are Dispensable for Establishment, Maintenance, and Long-Term Function of Human Centromeres. Dev Cell 40, 104-113
28073008   Curated Info

4

Yu Z, et al. (2015) Dynamic Phosphorylation of CENP-A at Ser68 Orchestrates Its Cell-Cycle-Dependent Deposition at Centromeres. Dev Cell 32, 68-81
25556658   Curated Info

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