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SEAyEMPsEEGYQDY SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 448278 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
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Downstream Regulation | |
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Effects of modification on SNCA: | |
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References | |
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Bétemps D, et al. (2023) Protease-Sensitive and -Resistant Forms of Human and Murine Alpha-Synucleins in Distinct Brain Regions of Transgenic Mice (M83) Expressing the Human Mutated A53T Protein. Biomolecules 13
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Wang Q, et al. (2023) Complement receptor 3-mediated neurotoxic glial activation contributes to rotenone-induced cognitive decline in mice. Ecotoxicol Environ Saf 266, 115550
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Min JO, et al. (2023) Statins suppress cell-to-cell propagation of α-synuclein by lowering cholesterol. Cell Death Dis 14, 474
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Gorecki AM, Spencer H, Meloni BP, Anderton RS (2023) The Poly-Arginine Peptide R18D Interferes with the Internalisation of α-Synuclein Pre-Formed Fibrils in STC-1 Enteroendocrine Cells. Biomedicines 11
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Albarran E, et al. (2023) Postsynaptic synucleins mediate endocannabinoid signaling. Nat Neurosci 26, 997-1007
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Vidyadhara DJ, et al. (2023) Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's disease. Cell Rep 42, 112231
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Killinger BA, et al. (2023) Distribution of phosphorylated alpha-synuclein in non-diseased brain implicates olfactory bulb mitral cells in synucleinopathy pathogenesis. NPJ Parkinsons Dis 9, 43
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Karuppagounder SS, et al. (2023) The c-Abl inhibitor IkT-148009 suppresses neurodegeneration in mouse models of heritable and sporadic Parkinson's disease. Sci Transl Med 15, eabp9352
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Ramalingam N, et al. (2023) Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity. NPJ Parkinsons Dis 9, 4
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Yong Y, et al. (2023) Dyrk1a Phosphorylation of -Synuclein Mediating Apoptosis of Dopaminergic Neurons in Parkinson's Disease. Parkinsons Dis 2023, 8848642
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Chiu YS, et al. (2023) Peptide immunization against the C-terminal of alpha-synuclein reduces locomotor activity in mice overexpressing alpha-synuclein. PLoS One 18, e0291927
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Ekmark-Lewén S, et al. (2023) Reduction of brain stem pathology and transient amelioration of early cognitive symptoms in transgenic mice treated with a monoclonal antibody against α-synuclein oligomers/protofibrils. Aging Brain 4, 100086
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Li G, et al. (2022) Chronic hypoxia leads to cognitive impairment by promoting HIF-2α-mediated ceramide catabolism and alpha-synuclein hyperphosphorylation. Cell Death Discov 8, 473
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Lassen LB, et al. (2022) Mutation of Tyrosine Sites in the Human Alpha-Synuclein Gene Induces Neurotoxicity in Transgenic Mice with Soluble Alpha-Synuclein Oligomer Formation. Cells 11
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Lashuel HA, et al. (2022) Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity. NPJ Parkinsons Dis 8, 136
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Kam TI, et al. (2022) Amelioration of pathologic α-synuclein-induced Parkinson's disease by irisin. Proc Natl Acad Sci U S A 119, e2204835119
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Yu D, et al. (2022) CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in huntington's disease. Acta Neuropathol Commun 10, 83
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Lv YQ, et al. (2022) Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson's disease mouse model. Transl Neurodegener 11, 14
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Uçar B, Stefanova N, Humpel C (2022) Spreading of Aggregated α-Synuclein in Sagittal Organotypic Mouse Brain Slices. Biomolecules 12
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Liu W, et al. (2022) Characterization of a Novel Monoclonal Antibody for Serine-129 Phosphorylated α-Synuclein: A Potential Application for Clinical and Basic Research. Front Neurol 13, 821792
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Jovanovic P, et al. (2022) Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy. PLoS One 17, e0263074
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Song MK, Adams L, Lee JH, Kim YS (2022) NXP031 prevents dopaminergic neuronal loss and oxidative damage in the AAV-WT-α-synuclein mouse model of Parkinson's disease. PLoS One 17, e0272085
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Morawska MM, et al. (2021) Slow-wave sleep affects synucleinopathy and regulates proteostatic processes in mouse models of Parkinson's disease. Sci Transl Med 13, eabe7099
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Tolve M, et al. (2021) The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons. Cell Rep 36, 109697
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Glajch KE, et al. (2021) Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proc Natl Acad Sci U S A 118
34326260 Curated Info |
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Zhang S, et al. (2021) Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease. Proc Natl Acad Sci U S A 118
34172566 Curated Info |
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Delaidelli A, et al. (2021) α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response. Acta Neuropathol Commun 9, 105
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Zhao M, et al. (2021) The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson's disease. Cell Death Differ
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Merghani MM, et al. (2021) Dose-related biphasic effect of the Parkinson's disease neurotoxin MPTP, on the spread, accumulation, and toxicity of α-synuclein. Neurotoxicology 84, 41-52
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Weston LJ, et al. (2021) Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies. J Biol Chem, 100273
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Zhang D, et al. (2021) Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson's disease model. J Neuroinflammation 18, 4
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Matsuo K, et al. (2021) Crucial Role of FABP3 in αSyn-Induced Reduction of Septal GABAergic Neurons and Cognitive Decline in Mice. Int J Mol Sci 22
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Polinski NK, et al. (2021) Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model. PLoS One 16, e0252325
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Elfarrash S, et al. (2021) Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein. PLoS One 16, e0252635
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Leem YH, et al. (2020) Papaverine inhibits ¿¿-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease. Biomed Pharmacother
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Tan Y, et al. (2020) LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 ¿¿-Synuclein in Mice Treated With Acute or Sub-Acute MPTP. Front Pharmacol
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Mahul-Mellier AL, et al. (2020) The process of Lewy body formation, rather than simply ¿¿-synuclein fibrillization, is one of the major drivers of neurodegeneration. Proc Natl Acad Sci U S A
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Challis C, et al. (2020) Gut-seeded ¿¿-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice. Nat Neurosci
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Davis AA, et al. (2020) APOE genotype regulates pathology and disease progression in synucleinopathy. Sci Transl Med
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Wang Y, et al. (2016) The novel mechanism of rotenone-induced α-synuclein phosphorylation via reduced protein phosphatase 2A activity. Int J Biochem Cell Biol 75, 34-44
27012437 Curated Info |
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Rutherford NJ, Brooks M, Giasson BI (2016) Novel antibodies to phosphorylated α-synuclein serine 129 and NFL serine 473 demonstrate the close molecular homology of these epitopes. Acta Neuropathol Commun 4, 80
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Volpicelli-Daley LA, et al. (2011) Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron 72, 57-71
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Liu C, et al. (2007) Assembly of lysine 63-linked ubiquitin conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis. J Biol Chem 282, 14558-66
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