|
Powered by Cell Signaling Technology |
Site Information |
---|
VsGQLIDsMANsFVG SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 448514 |
In vivo Characterization | |
---|---|
Methods used to characterize site in vivo: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
---|---|
Regulatory protein: | |
Putative in vivo kinases: | |
Kinases, in vitro: | |
Treatments: |
Downstream Regulation | |
---|---|
Effects of modification on MEK1: |
References | |
---|---|
Donaubauer EM, Law NC, Hunzicker-Dunn ME (2016) Follicle-Stimulating Hormone (FSH)-dependent Regulation of Extracellular Regulated Kinase (ERK) Phosphorylation by the Mitogen-activated Protein (MAP) Kinase Phosphatase MKP3. J Biol Chem 291, 19701-12
27422819 Curated Info |
|
Stankiewicz TR, et al. (2015) Neuronal Apoptosis Induced by Selective Inhibition of Rac GTPase versus Global Suppression of Rho Family GTPases Is Mediated by Alterations in Distinct Mitogen-activated Protein Kinase Signaling Cascades. J Biol Chem 290, 9363-76
25666619 Curated Info |
|
Flinder LI, et al. (2011) EGF-induced ERK-activation downstream of FAK requires rac1-NADPH oxidase. J Cell Physiol 226, 2267-78
21660950 Curated Info |
|
Park ER, Eblen ST, Catling AD (2007) MEK1 activation by PAK: a novel mechanism. Cell Signal 19, 1488-96
17314031 Curated Info |
|
Samuelsson AM, et al. (2006) Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways. Am J Physiol Heart Circ Physiol 291, H787-96
16565309 Curated Info |
|
Pinzar E, et al. (2005) Angiotensin II induces tyrosine nitration and activation of ERK1/2 in vascular smooth muscle cells. FEBS Lett 579, 5100-4
16139272 Curated Info |
|
Mao L, et al. (2005) Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons. J Biol Chem 280, 12602-10
15661743 Curated Info |
|
Slack-Davis JK, et al. (2003) PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation. J Cell Biol 162, 281-91
12876277 Curated Info |
|
Gil C, Chaib-Oukadour I, Aguilera J (2003) C-terminal fragment of tetanus toxin heavy chain activates Akt and MEK/ERK signalling pathways in a Trk receptor-dependent manner in cultured cortical neurons. Biochem J 373, 613-20
12710887 Curated Info |
|
Reusch HP, et al. (2001) Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells. J Biol Chem 276, 33630-7
11443134 Curated Info |
|
Yan M, Templeton DJ (1994) Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase. J Biol Chem 269, 19067-73
8034665 Curated Info |
|
Alessi DR, et al. (1994) Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J 13, 1610-9
8157000 Curated Info |
|
Saito Y, et al. (1994) The threonine residues in MAP kinase kinase 1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor-stimulated rat phaeochromocytoma (PC12) cells. FEBS Lett 341, 119-24
8137910 Curated Info |