Ser23
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Home > Phosphorylation Site Page: > Ser23  -  IkB-beta (mouse)

Site Information
WCDsGLGsLGPDAAA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447916

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
D-galactosamine ( 1 ) , LLnL ( 3 ) , LPS ( 1 , 3 ) , Oridonin ( 1 )

Downstream Regulation
Effects of modification on IkB-beta:
protein degradation ( 2 , 3 )

References 

1

Shi M, et al. (2019) Protective Effects of Oridonin on Acute Liver Injury via Impeding Posttranslational Modifications of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) in the Toll-Like Receptor 4 (TLR4) Signaling Pathway. Mediators Inflamm 2019, 7634761
31611735   Curated Info

2

Shirane M, et al. (1999) Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1. J Biol Chem 274, 28169-74
10497169   Curated Info

3

Weil R, Laurent-Winter C, Israƫl A (1997) Regulation of IkappaBbeta degradation. Similarities to and differences from IkappaBalpha. J Biol Chem 272, 9942-9
9092533   Curated Info