Ser228
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.8.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser228  -  Fe65 (human)

Site Information
DSSWATLsQGSPSYG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 36841900

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 2 )

Upstream Regulation
Putative in vivo kinases:
ATM (human) ( 2 ) , ATR (human) ( 2 )
Treatments:
AZ20 ( 2 ) , ionizing_radiation ( 2 ) , KU-55933 ( 2 ) , UV ( 1 , 2 )

Downstream Regulation
Effects of modification on biological processes:
transcription, inhibited ( 2 )

References 

1

Langlands H, Blain PG, Jowsey PA (2016) Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage. PLoS One 11, e0155056
27176072   Curated Info

2

Jowsey PA, Blain PG (2015) Fe65 Ser228 is phosphorylated by ATM/ATR and inhibits Fe65-APP-mediated gene transcription. Biochem J 465, 413-21
25397632   Curated Info

PhosphoSitePlus® is a registered trademark of Cell Signaling Technology.
Use of PSP data is subject to a formal license agreement. Learn more

©2003-2025 Cell Signaling Technology, Inc.