Ser196
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Home > Phosphorylation Site Page: > Ser196  -  CASP9 (human)

Site Information
kLRRRFssLHFMVEV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448454

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mass spectrometry ( 4 ) , mutation of modification site ( 4 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
lymphoma ( 2 ) , PEL ( 2 )
Relevant cell line - cell type - tissue:
'muscle, smooth' ( 1 ) , 267 (epithelial) ( 4 ) , BC3 (B lymphocyte) ( 2 ) , brain ( 3 ) , HEK293T (epithelial) ( 4 )

Upstream Regulation
Regulatory protein:
PLK1 (human) ( 1 )
Putative in vivo kinases:
Akt1 (human) ( 4 )
Kinases, in vitro:
Akt1 (human) ( 4 )
Treatments:
AG1296 ( 1 ) , derivative-2 ( 2 ) , EGF ( 1 ) , hypoxia ( 3 ) , IL-13 ( 1 ) , IL-33 ( 1 ) , PDGF ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on CASP9:
activity, inhibited ( 4 )
Effects of modification on biological processes:
apoptosis, induced ( 4 ) , apoptosis, inhibited ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
asthma ( 1 )

References 

1

Liao G, Wang R, Tang DD (2021) Plk1 Regulates Caspase-9 Phosphorylation at Ser-196 and Apoptosis of Human Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol
34705620   Curated Info

2

Watanabe T, et al. (2014) Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma. Biochem Biophys Res Commun 451, 93-100
25063029   Curated Info

3

Levenbrown Y, et al. (2008) Phosphorylation of caspase-9 in the cytosolic fraction of the cerebral cortex of newborn piglets following hypoxia. Neurosci Lett 447, 96-9
18840507   Curated Info

4

Cardone MH, et al. (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282, 1318-21
9812896   Curated Info

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