Tyr985
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Home > Phosphorylation Site Page: > Tyr985  -  LEPR (mouse)

Site Information
QRQPSVKyATLVSND   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448435

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 9 ) , mutation of modification site ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ) , phospho-antibody ( 1 , 10 ) , western blotting ( 1 , 9 )
Disease tissue studied:
adrenal cancer ( 8 ) , pheochromocytoma ( 8 ) , liver cancer ( 3 ) , obesity, hyperphagic ( 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 7 , 9 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 6 ) , COS (fibroblast) ( 6 ) , HEK293T (epithelial) ( 8 , 10 ) , HepG2 (hepatic) ( 3 ) , HIT-T15 (pancreatic) ( 5 ) , ovary ( 1 ) , PC-12 (chromaffin) ( 8 ) , RINm5F ( 3 )

Upstream Regulation
Treatments:
Epo ( 9 ) , high-fat diet ( 1 ) , leptin ( 1 , 6 , 10 )

Downstream Regulation
Effects of modification on LEPR:
activity, induced ( 5 ) , activity, inhibited ( 8 ) , molecular association, regulation ( 7 , 8 , 9 , 10 ) , phosphorylation ( 3 , 6 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 , 2 ) , transcription, altered ( 3 , 8 )
Induce interaction with:
SHP-2 (human) ( 7 ) , SHP-2 (mouse) ( 9 , 10 ) , SOCS3 (human) ( 7 ) , SOCS3 (mouse) ( 8 )

Disease / Diagnostics Relevance
Relevant diseases:
obesity, hyperphagic ( 2 )

References 

1

Wołodko K, et al. (2020) Leptin Resistance in the Ovary of Obese Mice is Associated with Profound Changes in the Transcriptome of Cumulus Cells. Cell Physiol Biochem 54, 417-437
32348667   Curated Info

2

You J, et al. (2010) Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance. Mol Cell Biol 30, 1650-9
20086094   Curated Info

3

Knobelspies H, et al. (2010) Mechanism of attenuation of leptin signaling under chronic ligand stimulation. BMC Biochem 11, 2
20059770   Curated Info

4

Björnholm M, et al. (2007) Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Invest 117, 1354-60
17415414   Curated Info

5

Hekerman P, et al. (2005) Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines. FEBS J 272, 109-19
15634336   Curated Info

6

Bjørbaek C, et al. (2001) Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem 276, 4747-55
11085989   Curated Info

7

Bjorbak C, et al. (2000) SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem 275, 40649-57
11018044   Curated Info

8

Eyckerman S, et al. (2000) Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor. FEBS Lett 486, 33-7
11108838   Curated Info

9

Banks AS, Davis SM, Bates SH, Myers MG (2000) Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 275, 14563-72
10799542   Curated Info

10

Li C, Friedman JM (1999) Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc Natl Acad Sci U S A 96, 9677-82
10449753   Curated Info

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