Tyr309
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Home > Phosphorylation Site Page: > Tyr309  -  BLK (human)

Site Information
VVTkEPIyIVTEyMA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3657873

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 3 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 2 )
Disease tissue studied:
brain cancer ( 2 ) , glioblastoma ( 2 ) , glioma ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 2 ) , U87MG (glial) ( 2 )

Upstream Regulation
Kinases, in vitro:
BLK (human) ( 2 )

Downstream Regulation
Effects of modification on BLK:
phosphorylation ( 2 )
Effects of modification on biological processes:
transcription, induced ( 2 )

References 

1

Li WW, et al. (2024) BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation. J Cell Biol 223
38078859   Curated Info

2

Li WW, et al. (2023) Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response. PLoS Pathog 19, e1011742
37871014   Curated Info

3

Gu T (2006) CST Curation Set: 2062; Year: 2006; Biosample/Treatment: tissue, bone marrow/-; Disease: acute myelogenous leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

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